| Identifiers | ||
| Product Name | OSU-03012 | |
| Catalogue No. | CM901511 | |
| Description | Inhibitor of phosphoinositide-dependent kinase-1. OSU-03012 inhibited both recombinant 3-phosphoinositide-dependent kinase-1 activity and PC-3 cell viability with similar IC50 values of ~5 µM. Exposure of PC-3 cells to OSU-03012 led to Akt dephosphorylation and suppression of p70 S6 kinase activity. Moreover, overexpression of PDK-1 and Akt partially protected against OSU-03012-induced apoptosis. Screening in a panel of 60 cell lines and testing in PC-3 cells indicated that the mean concentration for total growth inhibition by OSU-03012 was about 3 µM. | |
| CAS Number | 742112-33-0 | |
| Formula | C26H19F3N4O• HCl | |
| MW | 496.9 Da | |
| Product Type | Inhibitor | |
| Grade | ≥99% | |
| Storage Condition | refer to Technology Column | |
| Brand | Packing | Pricing | Quote request |
| IL | 10 mg | Inquiry | Ask Quote |
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