| Identifiers | ||
| Product Name | WP-1130 | |
| Catalogue No. | CM860123 | |
| Description | Cell-permeable. WP1130 acts as a partly selective DUB (deubiquitinases) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37, which are known to regulate survival protein stability and 26S proteasome function. WP1130-mediated inhibition of tumor-activated DUBs results in downregulation of antiapoptotic and upregulation of proapoptotic proteins, such as MCL-1 and p53. Blocks JAK2 signaling via JAK2 ubiquitination. | |
| CAS Number | 856243-80-6 | |
| Formula | C₁₉H₁₈BrN₃O | |
| MW | 384.27 | |
| Grade | ≥98% by TLC | |
| Storage Condition | -20°C | |