| Identifiers | ||
| Product Name | Vatalanib, Free Base | |
| Catalogue No. | CM860118 | |
| Description | Cell-permeable. An inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC₅₀ = 77 nM) and VEGFR-2 (FLK-1/KDR, IC₅₀ = 37 nM), with slightly higher potency against the latter. At higher concentrations, other tyrosine kinases are also inhibited, including PDGFR-β (IC₅₀ = 580 nM), c-KIT (IC₅₀ = 730 nM), FLT-4 (IC₅₀ = 660 nM) and c-FMS (IC₅₀ = 1.4 µM). On the other hand, vatalanib is not active against the EGFR, c-SRC, v-ABL, and protein kinase Cα (IC₅₀ > 10 µM). | |
| CAS Number | 212141-54-3 | |
| Formula | C₂₀H₁₅ClN₄ | |
| MW | 346.81 | |
| Grade | ≥98% by HPLC | |
| Storage Condition | -20°C | |