| Identifiers | ||
| Product Name | Tubastatin A | |
| Catalogue No. | CM860109 | |
| Description | Cell-permeable. A potent and selective HDAC6 (histone deacetylase 6) inhibitor. Displays 1093-fold selectivity over HDAC1 (IC₅₀ values of 15 nM for HDAC6 vs 16.4 µM for HDAC1). Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8. In addition, it displayed over 1000-fold selectivity against all HDAC isoforms excluding HDAC8, where it displayed 54-fold selectivity. Tubastatin A displayed dose-dependent protection against HCA (homocysteic acid)-induced neuronal cell death starting at 5 µM with near complete protection at 10 µM. | |
| CAS Number | 1239262-52-2 | |
| Formula | C₂₀H₂₁N₃O₂.HCl | |
| MW | 371.86 | |
| Grade | ≥98% by HPLC | |
| Storage Condition | -20°C | |
| Brand | Packing | Pricing | Quote request |
| IL | 5 mg | Inquiry | Ask Quote |
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