| Identifiers | ||
| Product Name | Quizartinib | |
| Catalogue No. | CM860072 | |
| Description | Cell-permeable. A second generation FLT3 receptor tyrosine kinase inhibitor. Quizartinib displays high affinity for FLT3 in a binding assay (Kd = 1.6 nM) and is a potent inhibitor in cellular autophosphorylation assays (IC₅₀ = 1.1 nM for FLT3-ITD and 4.2 nM for wt FLT3). It inhibits the growth of human leukemia cell line MV4-11 (IC₅₀0 = 0.56 nM) which is FLT3 dependent and contains a homozygous FLT3-ITD mutation, and A375 cells (IC50 > 10,000 nM) which are not FLT3 dependent and contain an activating mutation in BRAF. | |
| CAS Number | 950769-58-1 | |
| Formula | C₂₉H₃₂N₆O₄S | |
| MW | 560.67 | |
| Grade | ≥99% by HPLC | |
| Storage Condition | -20°C | |