| Identifiers | ||
| Product Name | Canertinib (CI-1033, PD-183805) | |
| Catalogue No. | CM812022 | |
| Description | Canertinib is an irreversible tyrosine kinase inhibitor. It not only inhibits tyrosine phosphorylation but also enhances ubiquitinylation and accelerates endocytosis and subsequent intracellular destruction of ErbB-2 molecules. Canertinib alkylates a cysteine residue specific to ErbB receptors. The degradative pathway of ErbB receptor tyrosine kinases stimulated by tyrosine kinase inhibitors appears to be chaperone mediated, and thus is similar to the pathways activated by the heat shock protein 90 (Hsp90) antagonist geldanamycin and by stress-induced mechanisms. | |
| Application | 5 mg. Purity >99%. CAS1 289499-45-2. Canertinib (CI-1033, PD183805) effectively inhibits the growth of esophageal squamous cell carcinoma which co-expresses both EGFR and HER2 with the inhibition of phosphorylation of both MAPK and AKT. CI-1033 was highly potent against EGFR (IC50 0.8 nM), HER-2 (IC50 19 nM) and ErbB-4 (IC50 7 nM). Soluble in DMSO. Store cool and dry at -20C. Protect from light. | |
| CAS Number | 289499-45-2 | |
| Formula | C₂₄H₂₅ClFN₅O₃ . 2HCl | |
| MW | 558.86 | |
| Storage Condition | -20°C | |
| Brand | Packing | Pricing | Quote request |
| IL | 5 mg | Inquiry | Ask Quote |
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