| Identifiers | ||
| Product Name | ABT-869 | |
| Catalogue No. | CM726056 | |
| Description | ABT-869 is multi-targeted inhibitor of all members of the VEGF and PDGF receptor families (e.g., KDR, IC₅₀ value of 4 nM), but has much less activity (IC₅₀ values >1 µM) against unrelated receptor tyrosine kinases, soluble tyrosine kinases or serine/threonine kinases. The kinase inhibition profile of ABT-869 is evident in cellular assays of RTK phosphorylation (IC₅₀ values of 2, 4 and 7 nM for PDGFRβ, KDR and CSF-1R, respectively) and VEGF-stimulated proliferation (0.2 nM IC₅₀ for human endothelial cells). | |
| Application | 5 mg. Purity >99%. CAS# 796967-16-3. ABT-869 is multi-targeted in that it is a potent inhibitor of all members of the VEGF and PDGF receptor families (e.g., KDR IC50 value of 4 nM), but has much less activity (IC50 values >1 µM) against unrelated receptor | |
| CAS Number | 796967-16-3 | |
| Formula | C₂₁H₁₈FN₅O | |
| MW | 375.41 | |
| Storage Condition | -20°C | |
| Brand | Packing | Pricing | Quote request |
| IL | 5 mg | Inquiry | Ask Quote |
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