| Identifiers | ||
| Product Name | T-Cell Death-Associated Gene 8 (GPR65) | |
| Catalogue No. | CM526094 | |
| Description | GPR65 (TDAG8), a Lysophospholipid/Lysosphingolipid Receptor, is a molecular target for psychosine, a toxic lipid formed by the breakdown of galactosylceramide (cerebroside). A build-up of psychosine, caused by the lack of galactosylceramidase, results in the death of the myelin-synthesizing cells, oligodendrocytes, which is associated with Krabbe disease. Recent evidence suggests that GPR65 is one of the proton-sensing GPCRs coupling to adenylyl cyclase and psychosine and its related lysosphingolipids behave as if they were antagonists against protein-sensing receptors, including TDAG8, GPR4 and OGR1 (Wang et al. 2004.) GPR65 has been reported in human in peripheral blood leukocytes, spleen, lymph node, and thymus. ESTs have been isolated from human B-cell/lung/testis, brain/lung/testis, pancreas/spleen, lung/spleen, leukocyte, embryo, kidney, liver/spleen, thyroid, and vessel libraries. | |
| Host | Rabbit | |
| Storage Condition | Long term: -70°C; Short term: -4°C | |
| Brand | Packing | Pricing | Quote request |
| IL | 50 ul | Inquiry | Ask Quote |
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