| Identifiers |
 |
| Product Name |
JC-1 |
| Catalogue No. |
CM260573 |
|
Description |
JC-1 is a mitochondrial dye that stains mitochondria in living cells in a membrane potential-dependent fashion. JC-1 monomer is in equilibrium with so called J-aggregates, which are favored at higher mitochondrial membrane potential. The monomer JC-1 has green fluorescence (lem = 527 nm), while the J-aggregates have red fluorescence (lem = 590 nm). Therefore, it has been possible to use fluorescence ratioing technique to study mitochondrial membrane potential. JC-1 is particularly useful for apoptosis studies. In apoptotic cells, the dye stays in the cytoplasm and fluoresces green, while in healthy cells, the dye aggregates in the mitochondria and fluoresces red. |
|
Application |
5 mg. Fluorescent Probe for detecting the changes in the mitochondrial transmembrance potenetial. |
| CAS
Number |
3520-43-2 |
| Formula |
C₂₅H₂₇Cl₄IN₄ |
| MW |
652.23 |
| Storage
Condition |
-20°C |